About Us

Are you a highly talented and motivated

d Modelling & Simulation Scienti

ist with experience in the pharma, cosmetics, crop protection, flavoring, or chemistry industry? Do you enjoy driving innovation and setting new boundaries in System Toxicology and Risk Assessment? This position offers you this and more exciting work in an innovative and fast-paced environm

ent. ES

SQlabs is an innovative, internationally acting Contract Research Organization and a global leader in the development and application of the OSPwww.open-systems-pharmacology.orgSuite (). We are a research-focused provider of specialized computational analyses in the life sciences i

ndustry. T

To help us grow our global PBK/QST business , we are lo

ooking for a Senior Scientist Systems Toxic

cology (m/f/d) to strengthen our multi-disciplinary project teams for the successful completion of client goals. We collaborate with global corporations in the pharma and chemical industry, as well as start-ups in the life-science technology sector and academic and non-profit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized tre

atment of patients and protect the health of the animal and human life. esqLABS has attracted international players as sponsors for the OSP Software development. In addition, funding through national and EU-wide

research grants allows us to develop our core technologies continuous

sly.

Role

This role will engage in activities ranging from consultations on study design and regulatory requirements through the development and evaluation of models, the performance of simulations, and the presentat

ion

of results. Complement a dedicated high-performing

team of scientists Collaborate with colleagues on multi-disciplinary teams to implement quantitative modeling and simulation projects/programs and to provide risk assessment and PBK/QST consultation to other compan

y projects/programs Provide modeling and simulation consulting through advanced PBK, QST, and exposure-response modeling and simulation using the OSP-Suite (PK-Sim, MoBi

, R), or other tools Support risk assessment protocols, study conduct, data analysis, and report writing with the

support of colleagues Responsible for appropriateness of methods, integrity of data used for analysis, a

nd accuracy of results Regularly engage with clients regarding the strategic approach, project execution, presentation of results, regulatory implications, an

d messaging of findings Prepare final technical reports, synopses, executive summaries, and ot

her regulatory documents Ensure the provision of advanced literature searches for project/pr

ogram-related information Provide sophisticated written interpretation of material and integrate research findings into project/progr

am methodology and results Share findings with internal and external project teams; prepare abstracts, presentations, and pu

blication-ready manuscripts Provide mentoring and f

eedback to junior scientists Integrate knowledge of PBK and QST to provide guidance regarding proposed approaches to address risk assessment and r

egulatory approval challenges Expand scientific expertise through attendance and presentation at international, national, and regional scientific conferences, client mee

tings, and government meetings Develop and teach at OSP-Suite (PK-Sim, MoBi, R),

and other workshops and cour

rses

Your profile

Required Skills & Experience 5+ years (Principa

l 10+ years) of applied toxicology 3+ years (Principal 5+ year

s) of leading projects and programs 3+ years (Principal 5+ years) of experience in reg

ulatory applications of PBK modeling Good knowledge of regulatory requir

ements and guidelines for PBK and QST Strong experience presenting scient

ific results to professional audiences Extensive experience preparing, submitting, and receiving approval

for publications in scientific journals Mechanistic physiologically based ki

netic modeling and simulation experience Expert knowledge in domain-specific modeling software (e.g. PK-Sim

/MoBi, SimCyp, or GastroPlus or TK-plate) Excellent communic

ation, presentation, and leadership skills Relationship-building skills with the ability to work cl

osely with project leaders and team members Strong organization skills and abi

lity to handle multiple tasks simu

ltaneously Work well handling tight deadlines Grea

t critical-thinking and problem-solving skills Fluency

in Englis

sh (oral and written), German is a plus Education PhD, or masters in quantitative sciences (Bioengineering, Applied Ma

th, ...) with advanced toxicology related training Or PharmD or PhD in pharmacology, toxicology, or related field

with advanced applied mathematics related training Further Qualities That Will Put You in the Spotlight Experience in regulatory submissions Advanced expertise in kinetic

s modeling software (e.g. NONMEM, Monolix, or IQRtools) Proficiency in a scripting language for m

odeling and simulation (ideally R, a

lternatively MATLAB) A strong understanding of statistics Strategic domain kno

wledge: Drug development, Crop p

rotection, Flavoring, e

etc. Published peer-reviewed articles

What's in Store for You

The dynamic team behind esqLABS unites people with different backgrounds, spanning disciplines like pharmaceutical sciences, physics, bioinformatics, mathematics, data science, and software engineering. Our trust in each other, our open-mindedness, and our constant quest for excellence and innovation unite us. We value flat hierarchies, where everyone can contribute ideas and expertise to develop the best product. We are passionate, always w

illing to broaden our horiz

ons, and love our start-up culture. You will also benefit from: Flexible work hours an

d a home office policy that focuse

s on people and not on numbers An attractive remuneration package A dedi

cated budget for education programs and conferences you can attend A working environment in which your contribution will make a differen

ce, and that allows you to take ownership of projects and proce

sses Res

sponsibility, autonomy, participation, and career perspective For more information about our culture,

values and benefits visit our Unique career opportunities - esqLABS

S GmbH . At esqLABS, we are committed to diverse backgrounds and experiences. #J-18808-Ljbffr